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REVIEW ARTICLE
Year : 2018  |  Volume : 15  |  Issue : 3  |  Page : 132-134

Novel drug - dinutuximab for high-risk neuroblastoma


1 Department of Paediatrics, Yenepoya Medical College and University, Mangalore, Karnataka, India
2 Department of Anaesthesia, Kasturba Medical College, Mangalore, Karnataka, India
3 Department of Pediatrics, Yenepoya Medical College, Mangalore, Karnataka, India

Correspondence Address:
Supriya Kushwah
Department of Paediatrics, Yenepoya Medical College and University, Deralakatte, Mangalore, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/am.am_14_17

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Neuroblastoma is the most common extracranial tumor in children aged <5 years. Prognosis of high-risk neuroblastoma is not good even after use of aggressive chemotherapy. Newer drug anti-GD2 monoclonal antibodies, dinutuximab in combination with granulocyte-macrophage colony-stimulating factor or interleukin-2, have been recently approved by Food and Drug Administration for the treatment of high-risk neuroblastoma. Dinutuximab binds to the glycolipid GD2 present on neuroblastoma cells and cells of neuroectodermal origin and enhances cell lysis through antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.


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