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Year : 2018  |  Volume : 15  |  Issue : 4  |  Page : 190-192

Metronidazole-induced encephalopathy

1 Department of Neurology, Institute of Neurosciences/Internal Medicine, Indraprastha Apollo Hospitals, New Delhi, India
2 Department of Neurology, Institute of Neurosciences, Indraprastha Apollo Hospitals, New Delhi, India

Correspondence Address:
Dinesh Mohan Chaudhari
L-428, Pocket L, Sarita Vihar, Near Mother Dairy, Mathura Road, New Delhi - 110 076
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/am.am_67_18

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Metronidazole, an antiparasitic and antibacterial compound, is one of the world's most widely used drugs. Metronidazole is available for the treatment in anaerobic infections but may produce a number of neurologic side effects, particularly after prolonged use, such as cerebellar involvement, encephalopathy, seizures, autonomic neuropathy, optic neuropathy, and peripheral neuropathy. Symptoms of encephalopathy and neuropathy may recover completely or partially after discontinuation of metronidazole. The incidence of metronidazole-induced encephalopathy (MIE) is unknown. We report a case of a 31-year-old man with liver abscess and history of few weeks use of metronidazole therapy presenting with multiple episodes of seizures and altered sensorium. Magnetic resonance imaging brain revealed diffuse uniform extensive altered signals and restricted diffusion in body and genu of corpus callosum, suggestive of MIE.

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