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Year : 2019  |  Volume : 16  |  Issue : 3  |  Page : 177-179

A case of paroxysmal nocturnal hemoglobinuria with renal hemosiderosis

Transplant Critical Care, Indraprastha Apollo Hospital, New Delhi, India

Correspondence Address:
Jayant Hota
Indraprastha Apollo Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/am.am_36_19

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Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal disorder of bone marrow. It is characterized by blood cells lacking membrane proteins that are normally attached by the glycosylphosphatidylinositol anchor. It usually presents with intravascular hemolysis, cytopenias, frequent infections, bone marrow hypoplasia, and a high incidence of life-threatening venous thrombosis. Kidney involvement is usually benign and secondary to chronic tubular deposition of hemosiderin. Acute kidney injury may occur in association with a hemolytic crisis. Here, we report a case of a 50-year-old male with hematuria, pancytopenia, and acute renal failure due to PNH. Renal biopsy demonstrated acute tubular necrosis with considerable hemosiderin deposition (hemosiderosis), but no evidence of vascular thrombosis.

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